Pampiri ea morao-rao e hatisitsoeng ho Journal of Physiology e ile ea tebisa nyeoe bakeng sa liphello tse khothalletsang bocha tsa ho ikoetlisa ka lintho tse phelang tse tsofalang, ho haha mosebetsi o fetileng o entsoeng ka litoeba tsa lab haufi le qetello ea bophelo ba bona ba tlhaho ba neng ba khona ho fumana lebili le boima la boikoetliso.
Pampiri e nang le lintlha tse ngata, "Saeno ea limolek'hule e hlalosang ho ikamahanya le botsofali le ka hare ho vivo karolo ea reprogramming mesifa ea skeletal," e thathamisa bangoli-'moho le bona ba 16, bao ba tšeletseng ba bona ba amanang le U of A. Mongoli ea tsamaisanang le eena ke Kevin Murach, motlatsi oa moprofesa Lefapheng la A la Bophelo bo Botle, Tšebetso ea Batho le Boithapollo, 'me mongoli oa pele ke Ronald G. Jones III, Ph.D.seithuti sa Laboratori ea Taolo ea Mesifa ea Murach ea Murach.
Bakeng sa pampiri ena, bafuputsi ba ile ba bapisa litoeba tsa botsofali tse neng li khona ho fumana lebili la boikoetliso bo boima le litoeba tse neng li entsoe ka epigenetic reprogramming ka polelo ea lintlha tsa Yamanaka.
Lintlha tsa Yamanaka ke lintlha tse 'ne tsa transcript tsa protheine (tse tsejoang e le Oct3/4, Sox2, Klf4 le c-Myc, hangata li khutsufatsoa ho OKSM) tse ka khutlisetsang lisele tse boletsoeng haholo (joalo ka sele ea letlalo) ho khutlela seleng ea stem, e leng boemo bo monyane le bo fetohang.Moputso oa Nobel oa Physiology kapa Medicine o ile oa fuoa Dr. Shinya Yamanaka bakeng sa tšibollo ena ka 2012. Ka litekanyetso tse nepahetseng, ho kenya lintlha tsa Yamanaka 'meleng ka litoeba ho ka ntlafatsa matšoao a botsofali ka ho etsisa ho ikamahanya le maemo ho tloaelehileng ho bacha ba bangata. lisele.
Har'a lintlha tse 'nè, Myc e susumetsoa ke ho sebelisa mesifa ea masapo.Myc e kanna ea sebetsa e le ts'usumetso ea tlhaho ea ho hlophisa bocha mesifa, e etsa hore e be ntlha ea bohlokoa ea papiso lipakeng tsa lisele tse hlophisitsoeng bocha ka lebaka la polelo ea lintlha tsa Yamanaka le lisele tse hlophisitsoeng bocha ka boikoetliso - "reprogramming" qetellong e bonts'a tšusumetso ea tikoloho e ka fetola ho fumaneha le ho hlahisa liphatsa tsa lefutso.
Bafuputsi ba ile ba bapisa mesifa ea marapo ea litoeba tse neng li lumeletsoe ho ikoetlisa ha nako e ntse e ea bophelong le mesifa ea skeletal ea litoeba tse neng li feteletsa OKSM mesifa ea tsona, hammoho le litoeba tse fetotsoeng ka liphatsa tsa lefutso tse lekanyelitsoeng ho overexpression ea Myc feela ka mesifa ea bona.
Qetellong, sehlopha se ile sa etsa qeto ea hore boikoetliso bo khothalletsa boemo ba limolek'hule bo lumellanang le lenaneo la karolo ea epigenetic.Ke ho re: boikoetliso bo ka etsisa likarolo tsa boemo ba limolek'hule tsa mesifa tse 'nileng tsa pepesetsoa lintlha tsa Yamanaka (ka hona li bontša litšobotsi tsa limolek'hule tsa lisele tse ngata tsa bocha).Phello ena e ntle ea boikoetliso e kanna ea bakoa ke liketso tse ikhethileng tsa Myc ka har'a mesifa.
Le hoja ho ka ba bonolo ho nahana hore ka letsatsi le leng re ka khona ho qhekella Myc ka mesifa ho finyella liphello tsa boikoetliso, kahoo ho re thibela ho sebetsa ka thata, Murach o hlokomelisa hore e ka ba qeto e fosahetseng ea ho e etsa.
Taba ea pele, Myc e ne e ke ke ea khona ho pheta-pheta litlamorao tsohle tseo boikoetliso bo nang le tsona 'meleng.Hape ke sesosa sa lihlahala le mofetše, ka hona ho na le likotsi tsa tlhaho tsa ho laola ponahalo ea eona.Sebakeng seo, Murach o nahana hore ho qhekella Myc ho ka sebelisoa hamolemo e le leano la liteko ho utloisisa mokhoa oa ho khutlisetsa boikoetliso ho mesifa ea khale e bonts'ang ho fokotseha ha karabelo.Mohlomong hape e ka ba mokhoa oa ho phahamisa karabelo ea bonohe ba linaleli ka matla a khoheli a zero kapa batho ba phomotseng betheng ba nang le matla a fokolang a ho ikoetlisa.Myc e na le litlamorao tse ngata, tse ntle le tse mpe, kahoo ho hlalosa tse molemo ho ka lebisa kalafong e bolokehileng e ka sebetsang hantle ho batho.
Murach o bona lipatlisiso tsa bona e le netefatso e eketsehileng ea boikoetliso joalo ka polypill.O re: "Ho ikoetlisa ke sethethefatsi se matla ka ho fetisisa seo re nang le sona," 'me se lokela ho nkoa e le phekolo ea bophelo bo botle - le e ka eketsang bophelo - hammoho le meriana le lijo tse phetseng hantle.
Bangoli-'moho le Murach le Jones ho U of A ba ne ba kenyelletsa moprofesa oa saense ea boikoetliso, Nicholas Greene, hammoho le bafuputsi ba kenyang letsoho Francielly Morena Da Silva, Seongkyun Lim le Sabin Khadgi.
Nako ea poso: Mar-02-2023